The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from animal studies in experimental studies.
Our mission is to provide evidence to inform translational medicine. Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate drugs for clinical trial.
CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for protocols of reviews in progress and of completed reviews.
While the CAMARADES data set is curated from Edinburgh it is mirrored at the National Stroke Research Institute in Melbourne Australia and is the shared property of all those contributing data.
The 2nd International Symposium on Systematic Reviews in Laboratory Animal Science took place in Edinburgh, 6-8th March, supported by the NC3Rs and the MRC Trials Methodology Hub: Pdf's of talks will be available here shortly
The 1st International Symposium on Systematic Reviews in Laboratory Animal Science took place in Nijmegen, 8-10th February: Talks are available on YouTube via this link
We team up with the Ioannidis group to show excess significance across a range of in vivo disease models
Evelien Rooke and Hanna Vesterinen tackle the animal modelling of Parkinson's Disease, and find low levels of reporting of measures to avoid bias
We were delighted contribute to the Nature Perspective calling for greater transparency in in vivo research
A fantastic project from medical student Theo Hurst looking at the in vivo data for temozolomide, a treatment for brain tumours
Hanna Vesterinen's paper shows that problems of internal and external validity are also common in the experimental allergic encephalomyelitis literature