A Rough Guide ...

Systematic searching…

The purpose of the systematic search strategy is to avoid bias in the selection of data for inclusion. It seems likely that there is a much greater risk of non-publication of animal data than of clinical trial data, and in addition much data may have been derived for internal Pharmaceutical Company use. So getting as much of the data as possible is of crucial importance.

One group (Macleod/Kelly/Bath/Roberts/Sandercock) is currently seeking funding to find out the optimal search strategy. In the meantime, a search strategy might involve …

Electronic database search - Pubmed, EMBASE, BIOSIS

Hand searching of conference abstracts

Email with the authors of included studies

Contact with the manufacturer of the drug in question

Two reviewers should then independently extract publications matching previously stated criteria, with differences resolved by discussion.

We have recently migrated to an MS Access based analysis system. However, the following may be useful...

Publication summary sheet ...

Meta-analysis - How to do it …

MS Excel meta - analysis engine (tPA data) ...

To contact us:

Malcolm Macleod
Department of Clinical Neurosciences
University of Edinburgh
Edinburgh, UK

EH4 2XU

Phone: 44-7786-265166
Fax: 44-131-5371132
E-mail:
malcolm@camarades.info