Protocols for Systematic Reviews of Animal Studies

Making the protocol for your systematic review available to the community has a number of benefits; it provides evidence that prespecified analyses were indeed prespecified; allows others to comment on your approach; provides examples for others planning such reviews; and can help you identify if other reviews in similar areas are already in progress.

This service is very much in development, but if you would like us to make a copy of your protocol available here please email

1. Protocol for a systematic review of methods using animal models for assessing antinociceptive effects of medicinal plants. available here; for further information contact Graciela Silva Rocha, Newcaslte University, UK

2. Non-surgical treatment of acute ischemic stroke in animal models: a systematic review and meta-analysis available here; for further information contact Jun Xia, Chongquing Military Hospital, China

3. A Systematic Review and Meta-analysis of the Efficacy of Edaravone in Animal Models of Focal Ischaemic Stroke"; for further information contact Simao Wu., University of Edinburgh

4. An analysis of any association between Impact Factor and reporting of measures to reduce bias; Protocol dated 13/3/13 posted 29/3/13. Contact Malcolm Macleod.

5. Systematic Review and Stratified Meta-Analysis of the Efficacy of Rho GTPase kinase (ROCK) Inhibitors and RhoA Inhibitors on Ischemic Stroke Animal Models. Protocol dated 11th September 2012 posted 27th May 2013. Contact Hanna Vesterinen Published article here

6. Systematic review and meta-analysis of decompression in animal models of traumatic spinal cord injury. Protocol of June 2013 posted 7th July 2013 replaces previous protocol of February 2012 posted 5th June 2013. Contact Taryn Wills

7. Systematic review and meta-analysis of hypothermia treatment in animal models of traumatic spinal cord injury. Protocol of November 2011 posted 12th June 2013. Contact Taryn Wills

8. Efficacy of antidepressants in animal models of ischaemic stroke. A systematic review and meta-analysis. Protocol of 13th June 2013 posted 13th June 2013. Contact Sarah Mccann

9. Are changes in cerebral blood flow contributing to the attenuation of brain injury by neuroprotective agents following ischaemic stroke? Protocol of 24th July posted 24th July 2013. Contact Brad Sutherland

10. Systematic Review and Stratified Meta-Analysis of the Efficacy of Rho-A-ROCK blockade intervention on locomotor recovery in animal models of traumatic Spinal Cord Injury Protocol of 27th July 2013 posted 2nd August 2013. Contact Ralf Watzlawick

11. Potential signalling pathways in human lacunar stroke: A systematic review and meta-analysis of therapeutic strategies in animal models Protocol of 30/1/12, revised October 2013, posted 16/10/13. Contact Malcolm Macleod

12. Stem cell transplantation in traumatic spinal cord injury: A systematic review and meta-analysis. Protocol of July 2013. Contact Malcolm Macleod

13. Systematic review of animal models in lympoedema research. Protocol of November 2013. Contact Florian Frueh

14. Effect of Chicken Egg Yolk Antibodies (IgY) against Diarrhea in Domesticated Animals: A Systematic Review and Meta-analysis. Protocol of Novemebr 2013, revised January 2014. Contact Diraviyam Thirumalai

15. Efficacy and safety of mesenchymal stromal cell therapy in preclinical models of acute lung injury: a systematic review Protocol of June 2013, posted March 2014. Contact Lauralyn McIntryre


Excess significance in animal studies

We team up with the Ioannidis group to show excess significance across a range of in vivo disease models

Dopamine Agonists in Parkinson's Disease

Evelien Rooke and Hanna Vesterinen tackle the animal modelling of Parkinson's Disease, and find low levels of reporting of measures to avoid bias

Call for increased transparency

We were delighted contribute to the Nature Perspective calling for greater transparency in in vivo research

Animal models of brain cancer

A fantastic project from medical student Theo Hurst looking at the in vivo data for temozolomide, a treatment for brain tumours

Improving the Translational Hit of MS Research

Hanna Vesterinen's paper shows that problems of internal and external validity are also common in the experimental allergic encephalomyelitis literature