Relevant publications from the CAMARADES collaborators

2011

Frantzias J, Sena ES, Macleod MR, Salman Ra-S. Treatment of Intracerebral Hemorrhage in Animal Models: Meta-Analysis. Ann Neurol 69, 389-399

Rooke EDM, Vesterinen HM, Sena ES, Egan KJ, Macleod MR. Dopamine agonists in animal models of Parkinson's disease: A systematic review and metas-analysis. Parkinsonism and Related Disorders

2010

Janssen H, Bernhardt J, Collier JM, Sena ES, McElduff P, Attia J, Pollack P, Howells DW, Nilsson M, Calford MB, Spratt NJ. An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke. Neurorehabil Neural Repair 24(9) 802-813

Macleod M, van der Worp HB. Animal models of neurological disease: are there
any babies in the bathwater? Pract Neurol. 10(6):312-4.

Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PAG, Macleod MR. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. JCBFM

Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol. 8(3):e1000344.

van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'Collins V, Macleod MR. Can animal models of disease reliably inform human studies? PLoS Med. 7(3):e1000245

Vesterinen HV, Egan K, Deister A, Schlattmann P, Macleod MR, Dirnagl U.
Systematic survey of the design, statistical analysis, and reporting of studies
published in the 2008 volume of the Journal of Cerebral Blood Flow and
Metabolism. J Cereb Blood Flow Metab.

O'Collins VE, Macleod MR, Cox SF, Van Raay L, Aleksoska E, Donnan GA, Howells DW. Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing. J Cereb Blood Flow Metab.

Vesterinen HM, Sena ES, ffrench-Constant C, Williams A, Chandran S, Macleod
MR. Improving the translational hit of experimental treatments in multiple
sclerosis. Mult Scler. 16(9):1044-55.

Howells DW, Porritt MJ, Rewell SS, O'Collins V, Sena ES, van der Worp HB,
Traystman RJ, Macleod MR. Different strokes for different folks: the rich
diversity of animal models of focal cerebral ischemia. J Cereb Blood Flow Metab.
30(8):1412-31.

Jerndal M, Forsberg K, Sena ES, Macleod MR, O'Collins VE, Linden T, Nilsson M, Howells DW. A systematic review and meta-analysis of erythropoietin in
experimental stroke. J Cereb Blood Flow Metab. 30(5):961-8.

2009

Bath PM, Macleod MR, Green AR. Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke. Int J Stroke. 4(6):471-9.

Dirnagl U, Macleod MR. Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice. Br J Pharmacol. 2009 Aug;157(7):1154-6. Epub 2009 Jun 23.

Banwell V, Sena ES, Macleod MR. Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke.  J Stroke Cerebrovasc Dis. 18(4):269-76.

Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M; STAIR VI Consortium. Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended  window acute stroke therapy trials. Stroke. 40(7):2594-600.

Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH; STAIR  Group. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 40(6):2244-50.

Amarasingh S, Macleod MR, Whittle IR. What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma. J Neurooncol. 2009 Jan;91(2):117-25.

Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW. Good laboratory practice: preventing introduction of bias at the bench. Stroke. 2009 Mar;40(3):e50-2.; reprinted in JCBFM and International Journal of Stroke

Cumberland Consensus Working Group, Cheeran B, Cohen L, Dobkin B, Ford G, Greenwood R, Howard D, Husain M, Macleod M, Nudo R, Rothwell J, Rudd A, Teo J, Ward N, Wolf S. The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke. Neurorehabil Neural Repair. 23(2):97-107.

2008

Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U and Donnan GA. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke 39: 2824-29

Crossley NA, Sena E, Goehler J, Horn J, van der Worp HB, Bath PMW, Macleod M, Dirnagl U. Empirical evidence of bias in the design of experimental stroke studies. Stroke, 39: 929-34

Wheble PCR, Sena ES and Macleod MR. A systematic review and meta-analysis of the efficacy of piracetam and piracetam– like compounds in experimental stroke. Cerebrovascular Disease 25: 5-11.  

2007

Sena E, van der Worp HB, Howells D and Macleod M. How can we improve the pre-clinical development of drugs for stroke?, Trends Neurosci.

van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR.  Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain.

Sena E, Wheble P, Sandercock P, Macleod M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke. 38(2):388-94.

Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock P, Macleod M, Mignini LE, Jayaram P, Khan KS. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ. 334(7586):197.  

2006

O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1,026 experimental treatments in acute stroke. Ann Neurol. 59(3):467-77.

2005

Macleod MR, Ebrahim S, Roberts I. Surveying the literature from animal experiments: systematic review and meta-analysis are important contributions. BMJ. 331(7508):110.

Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA. Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. J Cereb Blood Flow Metab. 25(6):713-21.

Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA. Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. J Pineal Res. 38(1):35-41.

2004

Macleod MR, O'Collins T, Howells DW, Donnan GA. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke. 35(5):1203-8.